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AIDS Res Hum Retroviruses. 2013 Jun;29(6):963-70. doi: 10.1089/AID.2013.0009. Epub 2013 Apr 18.

Dynamics of HIV type 1 recombination following superinfection.

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1
Virus Reference Department, Public Health England, London, UK. fransje.koning@phe.gov.uk

Abstract

There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.

PMID:
23495713
PMCID:
PMC3653373
DOI:
10.1089/AID.2013.0009
[Indexed for MEDLINE]
Free PMC Article

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