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Cell Biol Int. 2013 May;37(5):397-405. doi: 10.1002/cbin.10064. Epub 2013 Mar 13.

Vinculin, cell mechanics and tumour cell invasion.

Author information

1
Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Germany. wgoldmann@biomed.uni-erlangen.de

Abstract

The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.

PMID:
23494917
DOI:
10.1002/cbin.10064
[Indexed for MEDLINE]

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