Format

Send to

Choose Destination
Curr HIV/AIDS Rep. 2013 Jun;10(2):142-51. doi: 10.1007/s11904-013-0157-9.

Use of antiretrovirals for HIV prevention: what do we know and what don't we know?

Author information

1
Department of Global Health, University of Washington, Seattle, WA 98104, USA. jbaeten@uw.edu

Abstract

Pre-exposure prophylaxis (PrEP), in which HIV uninfected persons with ongoing HIV risk use antiretroviral medications as chemoprophylaxis against sexual HIV acquisition, is a promising new HIV prevention strategy. Proof-of-concept that PrEP, as oral or vaginal topical tenofovir-based products, protects against sexual HIV acquisition has been demonstrated in clinical trials conducted among men who have sex with men and heterosexual men and women. The degree of HIV protection in these trials was strongly related to the level of adherence to PrEP. Many questions are yet unanswered--including how to motivate uptake of and sustain adherence to PrEP for HIV prevention, how much PrEP use is enough to achieve HIV protection, and the potential of "next-generation" PrEP agents to improve on this effective technology.

PMID:
23494772
PMCID:
PMC3644362
DOI:
10.1007/s11904-013-0157-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center