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J Comput Assist Tomogr. 2013 Mar-Apr;37(2):134-41. doi: 10.1097/RCT.0b013e31827ddad3.

Assessment of hepatic fatty infiltration using spectral computed tomography imaging: a pilot study.

Author information

1
Departments of Radiation Oncology and Radiology, Fudan University, Huadong Hospital, Shanghai, China. zhengxp@fudan.edu.cn

Abstract

OBJECTIVE:

The objective of this study was to investigate the feasibility of using monochromatic spectral computed tomography (CT) imaging to assess fatty infiltration in liver.

MATERIALS:

With spectral CT imaging, phantoms with known fat concentrations were studied for scanning parameter optimization, then 52 patients enrolled into 4 groups (healthy, mild, moderate, and severe fatty infiltration) received abdominal scanning. Based on reconstructed monochromatic images, hepatic attenuation was analyzed, and dual-energy subtraction imaging (DESI) was created for quantifying fat infiltration.

RESULTS:

Corresponding to various hepatic fat infiltrations, 4 characteristic CT attenuation curve patterns were described. In DESI images, only fat and fatty components appeared bright. For livers without abnormal fat deposition, isolated bright pixels were visualized (% area = 0.5% ± 0.3%). With hepatic fat accumulation increasing, more bright pixels appeared in subtraction images with percentages of total liver area involved in 2.5%, 6.7%, and 13.4% of mild, moderate, and severe fat infiltration cases, respectively (P < 0.05). The corresponding CT values were as follows: 1.33, 2.53, 8.69, and 16.4 Hounsfield units (P < 0.01), which correlated with the % DESI area values (r = 0.9811).

CONCLUSIONS:

Spectral CT imaging is a promising method to quantitatively assess hepatic fat content and fatty infiltration with advantages compared with conventional CT imaging.

PMID:
23493199
DOI:
10.1097/RCT.0b013e31827ddad3
[Indexed for MEDLINE]
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