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Pediatr Res. 2013 Jun;73(6):777-82. doi: 10.1038/pr.2013.49. Epub 2013 Mar 14.

Time-related arterial changes after allogeneic hematopoietic stem cell transplantation in children.

Author information

1
Department of Pediatric Cardiology, Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. maila.turanlahti@hus.fi

Abstract

BACKGROUND:

Metabolic syndrome is a frequent late effect in young adults after hematopoietic stem cell transplantation (HSCT) performed in childhood.

METHODS:

To further study the signs of cardiovascular changes in HSCT patients, we performed noninvasive vascular ultrasonic measurements of arterial stiffness and endothelial function in 25 children (median age: 11.2 y) and in 22 healthy matched controls.

RESULTS:

The distensibility of the common carotid artery (CCA) was significantly lower in the patients than in the controls (mean = 0.48, SD = 0.19 vs. mean = 0.64 mm Hg(-1) × 10(-2), SD = 0.28; P = 0.024). The distensibility decreased with time passed after HSCT (P = 0.009). The compliance of the CCA was decreased (mean = 0.10, SD = 0.04 vs. mean = 0.13 mm(2) × mm Hg(-1), SD = 0.05; P = 0.041), and the incremental elastic modulus (E inc) was higher in the patients than in the controls (mean = 2.05, SD = 0.7 vs. mean = 1.6 mm × 10(3), SD = 0.6; P = 0.019). E inc was associated with time passed after HSCT (P = 0.036). The size of the brachial artery and flow-mediated dilation did not differ between the groups.

CONCLUSION:

Early mechanical changes of the arterial wall were found at young age after HSCT. Ultrasonography may offer a noninvasive method to find early alterations of the vascular bed and to optimize prevention of atherosclerosis in HSCT patients.

PMID:
23493165
DOI:
10.1038/pr.2013.49
[Indexed for MEDLINE]
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