Format

Send to

Choose Destination
Iran J Basic Med Sci. 2011 Jul;14(4):308-17.

"Silymarin", a promising pharmacological agent for treatment of diseases.

Author information

1
Medical Toxicology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. These protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. Silymarin has cytoprotection activities due to its antioxidant activity and radical scavenging. The possible known mechanisms of action of silymarin protection are blockade and adjustment of cell transporters, p-glycoprotein, estrogenic and nuclear receptors. Moreover, silymarin anti-inflammatory effects through reduction of TNF-α, protective effects on erythrocyte lysis and cisplatin-induced acute nephrotoxicity have been indicated in some studies. Silymarin has also inhibited apoptosis and follicular development in patients undergoing IVF. Basis on such data, silymarin can be served as a novel medication in complementary medicine.

KEYWORDS:

Antioxidant; Cancer; Liver; Medicinal plant; Silymarin

PMID:
23492971
PMCID:
PMC3586829

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center