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Curr Opin Cell Biol. 2013 Jun;25(3):334-40. doi: 10.1016/j.ceb.2013.02.001. Epub 2013 Mar 13.

Functions of the centromere and kinetochore in chromosome segregation.

Author information

1
Department of Biochemistry, Stanford University Medical School, Stanford, CA 94305, United States.

Abstract

Centromeres play essential roles in equal chromosome segregation by directing the assembly of the microtubule binding kinetochore and serving as the cohesion site between sister chromatids. Here, we review the significant recent progress in our understanding of centromere protein assembly and how centromere proteins form the foundation of the kinetochore.

PMID:
23490282
PMCID:
PMC3687001
DOI:
10.1016/j.ceb.2013.02.001
[Indexed for MEDLINE]
Free PMC Article

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