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Transpl Infect Dis. 2013 Jun;15(3):306-13. doi: 10.1111/tid.12069. Epub 2013 Mar 15.

Influence of hepatitis C virus infection and high virus serum load on biliary complications in liver transplantation.

Author information

1
Medical Department II, Ludwig-Maximilians University, Campus Grosshadern, Munich, Germany. Sophia.Horster@med.uni-muenchen.de

Abstract

BACKGROUND:

Biliary complications (BCs) and recurrent hepatitis C virus (HCV) infection are among the major causes of morbidity and graft loss following liver transplantation. The influence of HCV on BCs has not been definitely clarified.

PATIENTS AND METHODS:

We performed a retrospective cohort study to analyze risk factors and outcome of post orthotopic liver transplantation (OLT) BCs in 352 liver transplant recipients over 12 years in Munich, Germany (n = 84 with HCV; living donor and re-OLT were excluded). BCs diagnosed with imaging techniques and abnormal liver enzyme pattern, requiring an intervention, were considered.

RESULTS:

In a multivariate analysis, HCV serostatus and a high pre-and post-surgery HCV RNA serum load were independent risk factors for anastomotic strictures. HCV positivity and BCs alone did not alter graft loss. HCV-positive patients with BCs, however, had a significantly worse graft outcome (P = 0.02). Non-anastomotic strictures, bile leaks, and the number of interventions needed to treat bile leaks led to worse graft outcome in all patients.

CONCLUSION:

HCV positivity and a high HCV RNA serum load were risk factors for anastomotic strictures. BCs and HCV had an additive effect on graft loss.

PMID:
23489913
DOI:
10.1111/tid.12069
[Indexed for MEDLINE]

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