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Oncoimmunology. 2013 Jan 1;2(1):e22059.

Improving the outcome of adoptive cell transfer by targeting tumor escape.

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Ovarian Cancer Research Center; University of Pennsylvania; Philadelphia, PA USA.


Adoptive T-cell transfer is among the most promising immunotherapies against cancer. To continue increasing the potential of this therapy, our studies focus on the inhibition of tumor recurrence. Recently, we have demonstrated several ways in which combination therapies involving multiple T-cell populations and immunostimulatory chemotherapy can enhance long-term survival.


adoptive T cell therapy; cyclophosphamide; immunostimulatory chemotherapy; melanoma; tumor escape

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