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Oncoimmunology. 2013 Jan 1;2(1):e22505.

Lymphoid neogenesis in melanoma: What does it tell us?

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Ludwig Institute for Cancer Research Ltd; Brussels, Belgium ; Medical Oncology Department; Centre du Cancer des Cliniques Universitaires Saint-Luc; Brussels, Belgium ; de Duve Institute; Université Catholique de Louvain; Brussels, Belgium.


Metastatic melanoma lesions sometimes host ectopic lymphoid structures exhibiting ongoing adaptive immune responses. Here, we discuss how this finding fits in our current view of antitumor immunity.


IgA; ectopic lymphoid structures; germinal center; humoral response; lymphoid neogenesis; melanoma; metastasis

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