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Oncoimmunology. 2013 Jan 1;2(1):e22892.

Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptors.

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Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Lisbon, Portugal.


The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-cell targeting by γδ T cells.


NK cell; NK receptor; NKG2D; T-cell receptor; γδ T cell

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