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Oncoimmunology. 2013 Jan 1;2(1):e22337.

NK cell-released exosomes: Natural nanobullets against tumors.

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Unit of Antitumor Drugs; Department of Therapeutic Research and Medicines Evaluation; Istituto Superiore di Sanità; Rome, Italy.


We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were obtained with circulating exosomes from human healthy donors. Both NK-cell derived and circulating exosomes exerted a full functional activity and killed both tumor and activated immune cells. These findings indicate that NK-cell derived exosomes might constitute a new promising therapeutic tool.


exosomes; nanomedicine; natural killer; perorin; theranostic

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