Send to

Choose Destination
See comment in PubMed Commons below
Oncoimmunology. 2013 Jan 1;2(1):e22653.

Involvement of STAT3 in immune evasion during lung tumorigenesis.

Author information

Department of Respiratory Medicine, Allergy and Rheumatic Diseases; Osaka University Graduate School of Medicine; Suita, Osaka, Japan.


In a recent study, we have shown that STAT3 expressed by tumor cells blunts antitumor immunity during carcinogen-induced lung tumorigenesis. STAT3 inhibits the production of pro-inflammatory chemokines and MHC Class I chain-related gene A. In contrast, STAT3 promotes the expression of MHC class I molecules. Consequently, STAT3 promotes tumor cell resistance to NK cell-mediated cytotoxicity.


MHC Class I; MICA; NK cell; STAT3; antitumor immunity; lung; tumorigenesis

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center