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Oncoimmunology. 2013 Jan 1;2(1):e22653.

Involvement of STAT3 in immune evasion during lung tumorigenesis.

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1
Department of Respiratory Medicine, Allergy and Rheumatic Diseases; Osaka University Graduate School of Medicine; Suita, Osaka, Japan.

Abstract

In a recent study, we have shown that STAT3 expressed by tumor cells blunts antitumor immunity during carcinogen-induced lung tumorigenesis. STAT3 inhibits the production of pro-inflammatory chemokines and MHC Class I chain-related gene A. In contrast, STAT3 promotes the expression of MHC class I molecules. Consequently, STAT3 promotes tumor cell resistance to NK cell-mediated cytotoxicity.

KEYWORDS:

MHC Class I; MICA; NK cell; STAT3; antitumor immunity; lung; tumorigenesis

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