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Int J Mol Sci. 2013 Mar 12;14(3):5723-33. doi: 10.3390/ijms14035723.

9G DNAChip Technology: Self-Assembled Monolayer (SAM) of ssDNA for Ultra-Sensitive Detection of Biomarkers.

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1
Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200-702, Korea. tskim@hallym.ac.kr.

Abstract

A 9G DNAChip obtained by allowing the formation of a self-assembled monolayer (SAM) of oligonucleotides appended with nine consecutive guanines on the chip surface has been applied in the detection of biomarkers. Using a 9G DNAChip, biomarker in the concentration range of 4 pg/mL to 40 fg/mL can be easily differentiated in the buffer matrix. Moreover, it is the first time that a biomarker with a concentration of 40 fg/mL has been detected in a mixture of proteins without use of any signal amplification technique.

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