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J Chromatogr A. 2013 Jul 26;1300:112-8. doi: 10.1016/j.chroma.2013.02.018. Epub 2013 Feb 14.

Preparation of magnetic molecularly imprinted polymer for selective recognition of resveratrol in wine.

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Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.


The magnetic molecularly imprinted polymers (MMIPs) for resveratrol were prepared by using surface molecular imprinting technique with a super paramagnetic core-shell nanoparticle as a supporter. Rhapontigenin, which is the analogues of resveratrol, was selected as dummy template molecules to avoid the leakage of trace amount of resveratrol. Acrylamide and ethylene glycol dimethacrylate were chosen as functional monomers and cross-linker, respectively. The obtained MMIPs were characterized by using scanning electron microscopy, Fourier transform infrared spectrum, X-ray diffraction and vibrating sample magnetometer. High performance liquid chromatography was used to analyze the target analytes. The resulting MMIPs exhibited high saturation magnetization of 53.14emug(-1) leading to the fast separation. The adsorption test showed that the MMIPs had high adsorption capacity for resveratrol and contained homogeneous binding sites. The MMIPs were employed as adsorbent of solid phase extraction for determination of resveratrol in real wine samples, and the recoveries of spiked samples ranged from 79.3% to 90.6% with the limit of detection of 4.42ngmL(-1). The prepared MMIPs could be employed to selectively pre-concentrate and determine resveratrol from wine samples.


Dummy template; MIPs; MISPE; MMIPs; MNIPs; Magnetic molecularly imprinted polymers; RH; Resveratrol; Wine samples; magnetic MIPs; magnetic non imprinted polymers; molecularly imprinted polymers; molecularly imprinted solid-phase extraction; rhapontigenin

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