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Org Lett. 2013 Apr 5;15(7):1492-5. doi: 10.1021/ol4002619. Epub 2013 Mar 12.

Two new types of bisindole alkaloid from Trigonostemon lutescens.

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1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, PR China.

Abstract

Six unprecedented bisindole alkaloids, trigolutesins A and B (1-2) with a unique polycyclic skeleton and trigolutes A-D (3-6) with another polycyclic skeleton, were isolated from the twigs of Trigonostemon lutescens. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography. Trigolutesin A (1) showed weak AChE inhibitory activity.

PMID:
23480691
DOI:
10.1021/ol4002619
[Indexed for MEDLINE]
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