Format

Send to

Choose Destination
J Med Primatol. 2013 Jun;42(3):120-31. doi: 10.1111/jmp.12043. Epub 2013 Mar 11.

The genetic composition of populations of cynomolgus macaques (Macaca fascicularis) used in biomedical research.

Author information

1
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA. skanthaswamy@ucdavis.edu

Abstract

BACKGROUND:

The genetic composition of cynomolgus macaques used in biomedical research is not as well-characterized as that of rhesus macaques.

METHODS:

Populations of cynomolgus macaques from Sumatra, Corregidor, Mauritius, Singapore, Cambodia, and Zamboanga were analyzed using 24 STRs.

RESULTS:

The Sumatran and Cambodian populations exhibited the highest allelic diversity, while the Mauritian population exhibited the lowest. Sumatran cynomolgus macaques were the most genetically similar to all others, consistent with an Indonesian origin of the species. The high diversity among Cambodian animals may result from interbreeding with rhesus macaques. The Philippine and Mauritian samples were the most divergent from other populations, the former due to separation from the Sunda Shelf by deepwater and the latter due to anthropogenic translocation and extreme founder effects.

CONCLUSIONS:

Investigators should verify their research subjects' origin, ancestry, and pedigree to minimize risks to biomedical experimentation from genetic variance stemming from close kinship and mixed ancestry as these can obscure treatment effects.

PMID:
23480663
PMCID:
PMC3651788
DOI:
10.1111/jmp.12043
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center