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J Proteome Res. 2013 Apr 5;12(4):1847-55. doi: 10.1021/pr301190g. Epub 2013 Mar 25.

Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors.

Author information

1
Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center , Leiden, The Netherlands.

Abstract

Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

PMID:
23480610
DOI:
10.1021/pr301190g
[Indexed for MEDLINE]

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