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Clin Microbiol Infect. 2013 Jun;19(6):E260-2. doi: 10.1111/1469-0691.12161. Epub 2013 Mar 11.

High-resolution melting analysis for the detection of two erythromycin-resistant Bordetella pertussis strains carried by healthy schoolchildren in China.

Author information

1
National Centre for Chronic and Non-communicable Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China. zhangqi@chinacdc.cn

Abstract

Two erythromycin-resistant strains of Bordetella pertussis were isolated from nasopharyngeal specimens of two asymptomatic schoolchildren in China. High-resolution melting and sequencing analyses confirmed the homogeneous A2047G mutation in 23S rRNA genes of the two isolates. High-resolution melting (HRM) analysis is a useful assay for the rapid detection of erythromycin-resistant B. pertussis. The appearance of erythromycin-resistant B. pertussis strains in China is alarming.

PMID:
23480481
DOI:
10.1111/1469-0691.12161
[Indexed for MEDLINE]
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