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J Addict Dis. 2013;32(1):68-78. doi: 10.1080/10550887.2012.759872.

A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.

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1
Primary Care Research Institute, Department of Family Medicine, State University of New York at Buffalo, Buffalo, New York, USA.

Abstract

Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00879996.

PMID:
23480249
PMCID:
PMC3604999
DOI:
10.1080/10550887.2012.759872
[Indexed for MEDLINE]
Free PMC Article
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