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Inhal Toxicol. 2013 Mar;25(4):192-8. doi: 10.3109/08958378.2013.773109.

Evaluation of effects of repeated sevoflurane exposure on rat testicular tissue and reproductive hormones.

Author information

1
Department of Anesthesiology and Reanimation, Gaziosmanpasa University School of Medicine, Tokat, Turkey. zkayaahz@gmail.com

Abstract

CONTEXT:

Evaluation of inhalation anesthetics on sperm and reproductive hormones are extremely important.

OBJECTIVE:

Investigation of the effects of sevoflurane used as an inhalation anesthetic on sperm morphology and reproductive hormones in rat testes.

MATERIALS AND METHODS:

Forty Wistar-Albino male rats were divided into five groups of eight rats each. The control group received 2 L/min oxygen for seven days, 2 h/day while sevoflurane treatment S1 received 1 minimal alveolar concentration (MAC) sevoflurane + 2 L/min oxygen for seven days, 2 h/day, and sevoflurane S2 received 1 MAC sevoflurane + 2 L/min oxygen for seven days, 2 h/day followed by seven days of no treatment. Sevoflurane treatment S3 received 1 MAC sevoflurane + 2 L/min oxygen for 14 days, 2 h/day and sevoflurane treatment S4 received 1 MAC sevoflurane + 2 L/min oxygen for 14 days, 2 h/day, with no treatment for the following seven days. All rats were examined histologically after experimental procedures. Rat luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and inhibin levels were measured.

RESULTS:

Histological injury scores were significantly higher in S2, S3, and S4 receiving sevoflurane in comparison to the control group (p = 0.001, <0.001, and 0.001, respectively). Sperm motility and concentration decreased in S3 and S4 compared to the control group (p = 0.03 and 0.02, respectively). Significant differences were detected among all groups for serum LH, FSH, T, and inhibin serum concentrations (p < 0.05).

CONCLUSION:

Testicular and sperm morphology, and reproductive hormones were affected by chronic exposure to sevoflurane. However, more randomized, controlled, and well-designed clinical studies with larger population are needed to confirm of these results.

PMID:
23480195
DOI:
10.3109/08958378.2013.773109
[Indexed for MEDLINE]

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