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Antimicrob Agents Chemother. 2013 May;57(5):2413-6. doi: 10.1128/AAC.00266-13. Epub 2013 Mar 11.

Novel 16S rRNA methyltransferase RmtH produced by Klebsiella pneumoniae associated with war-related trauma.

Author information

1
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Abstract

Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high MICs of all aminoglycosides, including arbekacin. A gene encoding a novel 16S rRNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.

PMID:
23478957
PMCID:
PMC3632941
DOI:
10.1128/AAC.00266-13
[Indexed for MEDLINE]
Free PMC Article

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