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Bull Environ Contam Toxicol. 2013 May;90(5):591-5. doi: 10.1007/s00128-013-0976-9. Epub 2013 Mar 12.

Interference of xenoestrogen o,p'-DDT on the action of endogenous estrogens at environmentally realistic concentrations.

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School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.


Estrogenic effects of individual chemicals and mixtures of 17β-estradiol (E2) and o,p'-DDT were examined using pS2 and PR gene expressions in MCF-7 cells. Interactions between E2 and o,p'-DDT were evaluated by a statistical method based on factorial design. At levels close to environmentally realistic concentrations, no significant interactions between E2 and o,p'-DDT were observed, suggesting that the xenoestrogen (o,p'-DDT) could act in an additive way with the endogenous estrogen (E2). These results demonstrated the utility of this statistical method in a mixture study, and highlight the potential interference and health risk of low-level xenoestrogens, such as o,p'-DDT.

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