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Int J Colorectal Dis. 2013 May;28(5):637-41. doi: 10.1007/s00384-013-1672-2. Epub 2013 Mar 12.

Trends in colorectal incidence by anatomic subsite from 1985 to 2005: a population-based study.

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1
Clinical and Descriptive Epidemiology Unit, Institute for Study and Cancer Prevention (ISPO), Via delle Oblate 2, 50141 Florence, Italy. a.caldarella@ispo.toscana.it

Abstract

BACKGROUND:

Conflicting results on the shift of right-left ratio in colon cancer incidence have been reported. We examine incidence trends by subsite in a population-based study.

MATERIALS AND METHODS:

Colorectal cancer cases diagnosed in the 1985-2005 period were identified through the Tuscany Cancer Registry. Colon subsite was defined as proximal and distal; gender, age at diagnosis, histology, and stage were analyzed. Average annual incidence and age-specific rates according to subsite were calculated.

RESULTS:

A total of 21,160 colorectal cancer cases were extracted; in 18,311 cases, the subsite was identified: 6,916 rectal, 5,239 proximal, and 6,156 distal. A larger proportion of distal colon cancers presented as early stage when compared with proximal. Incidence of rectal and distal colon cancer remained stable, while proximal colon cancer incidence increased.

CONCLUSIONS:

Proximal colon cancer incidence rate increased through the period. Temporal variations in the incidence rate by subsite could suggest different carcinogenic pathways of right- and left-sided colon cancer.

PMID:
23478843
DOI:
10.1007/s00384-013-1672-2
[Indexed for MEDLINE]
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