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Mol Cell. 2013 Apr 11;50(1):5-15. doi: 10.1016/j.molcel.2013.01.039. Epub 2013 Mar 7.

STING recognition of cytoplasmic DNA instigates cellular defense.

Author information

1
Department of Cell Biology and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Abstract

How the cell recognizes cytosolic DNA including DNA-based microbes to trigger host-defense-related gene activation remains to be fully resolved. Here, we demonstrate that STING (stimulator of interferon genes), an endoplasmic reticulum translocon-associated transmembrane protein, acts to detect cytoplasmic DNA species. STING homodimers were able to complex with self- (apoptotic, necrotic) or pathogen-related ssDNA and dsDNA and were indispensible for HSV-1-mediated transcriptional activation of a wide array of innate immune and proinflammatory genes in addition to type I IFN. Our data indicate that STING instigates cytoplasmic DNA-mediated cellular defense gene transcription and facilitates adoptive responses that are required for protection of the host. In contrast, chronic STING activation may manifest inflammatory responses and possibly autoimmune disease triggered by self-DNA.

PMID:
23478444
PMCID:
PMC3881179
DOI:
10.1016/j.molcel.2013.01.039
[Indexed for MEDLINE]
Free PMC Article

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