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Nat Rev Genet. 2013 Apr;14(4):262-74. doi: 10.1038/nrg3425. Epub 2013 Mar 12.

Genomic signatures of selection at linked sites: unifying the disparity among species.

Author information

1
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada. asher.cutter@utoronto.ca

Abstract

Population genetics theory supplies powerful predictions about how natural selection interacts with genetic linkage to sculpt the genomic landscape of nucleotide polymorphism. Both the spread of beneficial mutations and the removal of deleterious mutations act to depress polymorphism levels, especially in low-recombination regions. However, empiricists have documented extreme disparities among species. Here we characterize the dominant features that could drive differences in linked selection among species--including roles for selective sweeps being 'hard' or 'soft'--and the concealing effects of demography and confounding genomic variables. We advocate targeted studies of closely related species to unify our understanding of how selection and linkage interact to shape genome evolution.

PMID:
23478346
PMCID:
PMC4066956
DOI:
10.1038/nrg3425
[Indexed for MEDLINE]
Free PMC Article

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