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Chem Commun (Camb). 2013 Apr 18;49(30):3137-9. doi: 10.1039/c3cc40906f. Epub 2013 Mar 12.

An ultrasensitive chemiluminescence turn-on assay for protease and inhibitor screening with a natural substrate.

Author information

1
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.

Abstract

A highly sensitive and convenient chemiluminescence (CL) turn-on assay for protease without any label and synthesis has been developed. Cytochrome c was digested by a protease, and heme was released as a peptide-heme conjugate, which greatly enhanced the luminol-H2O2 CL reaction.

PMID:
23478332
DOI:
10.1039/c3cc40906f
[Indexed for MEDLINE]

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