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J Cyst Fibros. 2013 Dec;12(6):729-36. doi: 10.1016/j.jcf.2013.02.004. Epub 2013 Mar 9.

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs.

Author information

1
Department of International Health, Immunology and Microbiology, Unit of Bacteriology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: ociofu@sund.ku.dk.

Abstract

BACKGROUND:

Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations.

METHODS:

We studied the genetic basis of phenotypic diversification and gene expression profiles in sequential lung and sinus P. aeruginosa isolates from four chronically infected CF patients, including pre- and post-lung transplantation isolates.

RESULTS:

The same phenotypes caused by similar mutations and similar gene expression profiles were found in mucoid and non-mucoid isolates from the paranasal sinuses and from the lungs before and after transplantation.

CONCLUSION:

Bilateral exchange of P. aeruginosa isolates between the paranasal sinuses and the lungs occurs in chronically infected patients and extensive sinus surgery before the lung transplantation might prevent infection of the new lung.

PMID:
23478131
DOI:
10.1016/j.jcf.2013.02.004
[Indexed for MEDLINE]
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