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Trends Neurosci. 2013 Jun;36(6):315-24. doi: 10.1016/j.tins.2013.01.008. Epub 2013 Mar 13.

Neurons as targets for T cells in the nervous system.

Author information

1
Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse, France. roland.liblau@inserm.fr

Abstract

Accumulating evidence shows that T cells penetrate the central nervous system (CNS) parenchyma in several autoimmune, infectious, and degenerative neurological diseases. The structural and functional consequences for CNS neurons of their encounter with activated T cells have been investigated in several experimental systems, including ex vivo co-cultures, electrophysiology, and in vivo imaging. Here, we review the modalities of neuron/T cell interactions. We substantiate the contention that T cells are directly responsible for neuronal damage in a large number of neurological diseases and discuss mechanisms of neuronal damage mediated by distinct T cell subsets, the impact of which differs depending on the disease. Finally, we describe how a better understanding of the mechanisms at play offers new possibilities for therapeutic intervention.

PMID:
23478065
DOI:
10.1016/j.tins.2013.01.008
[Indexed for MEDLINE]

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