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Curr Opin Chem Biol. 2013 Apr;17(2):129-36. doi: 10.1016/j.cbpa.2013.01.009. Epub 2013 Mar 13.

Chelators for investigating zinc metalloneurochemistry.

Author information

1
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.

Abstract

The physiology and pathology of mobile zinc signaling has become an important topic in metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are required that probe the temporal and positional changes of zinc ions within live tissue and cells. In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.

PMID:
23478014
PMCID:
PMC3634875
DOI:
10.1016/j.cbpa.2013.01.009
[Indexed for MEDLINE]
Free PMC Article

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