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Comput Methods Biomech Biomed Engin. 2014 Nov;17(15):1705-15. doi: 10.1080/10255842.2013.763938. Epub 2013 Mar 12.

A two population model of prion transport through a tunnelling nanotube.

Author information

1
a Department of Biomedical Engineering , Johns Hopkins University , Baltimore , MD 21218-2694 , USA.

Abstract

This article develops a two prion population model that simulates prion trafficking between an infected dendritic cell and a neuron. The situation when the two cells are connected by a tunnelling nanotube (TNT) is simulated. Two mechanisms of prion transport are considered: lateral diffusion in the TNT membrane and active actin-dependent transport inside endocytic vesicles that are propelled by myosin Va molecular motors. Analytical solutions describing prion concentrations and fluxes are obtained. Numerical results are compared with those predicted by a single prion population model that relies on a single reaction-diffusion equation and accounts for the two modes of prion transport in an effective way.

KEYWORDS:

membrane nanotubes; modelling; molecular motors; prions; traffic

PMID:
23477810
DOI:
10.1080/10255842.2013.763938
[Indexed for MEDLINE]
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