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Atherosclerosis. 2013 May;228(1):256-8. doi: 10.1016/j.atherosclerosis.2013.02.020. Epub 2013 Feb 26.

Does the Framingham cardiovascular disease risk score also have predictive utility for dementia death? An individual participant meta-analysis of 11,887 men and women.

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1
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. tom.russ@nhs.net

Abstract

OBJECTIVE:

Individual cardiovascular disease (CVD) risk factors are associated with dementia. For the first time, we investigated whether the Framingham CVD risk score-which comprises these multiple risk factors-was also associated with future dementia risk.

METHODS:

Individual participant meta-analysis of two large, general population cohort studies (N = 11,887). For the purposes of comparison of the dementia results, we also examined the association between the Framingham CVD risk score and CVD-related death.

RESULTS:

Framingham CVD risk score was associated with dementia death (hazard ratio per 10% increased risk, 95% confidence interval: 4.00, 2.44-6.56). Adjusting for age eliminated this association (1.04, 0.53-2.01); similarly, age explained 88% of the ability of the Framingham CVD risk score to predict CVD death.

CONCLUSIONS:

The Framingham CVD risk score was no more strongly associated with future dementia than age. It therefore offers no added value in predicting dementia.

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