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Evid Based Complement Alternat Med. 2013;2013:272134. doi: 10.1155/2013/272134. Epub 2013 Feb 11.

Antiulcer Activity of Indigenous Plant Operculina turpethum Linn.

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Department of Pharmacology, Sathyabama University Dental College and Hospital, Sathyabama University, Jeppiaar Nagar, Rajiv Gandhi Road, Chennai, Tamilnadu 600 119, India.


In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.

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