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ScientificWorldJournal. 2013;2013:292687. doi: 10.1155/2013/292687. Epub 2013 Feb 13.

The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis.

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1
Department of Anaesthesiology and Reanimation, School of Medicine, Dokuz Eylül University, Inciralti, 35340 İzmir, Turkey. ugur.koca@deu.edu.tr

Abstract

In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-induced lung and kidney injuries and apoptosis in the rat model of sepsis. There is still need for comparative studies in order to determine the effects of dexmedetomidine on organ functions in early human sepsis.

PMID:
23476127
PMCID:
PMC3586481
DOI:
10.1155/2013/292687
[Indexed for MEDLINE]
Free PMC Article
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