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Cereb Cortex. 2014 Aug;24(8):2036-54. doi: 10.1093/cercor/bht056. Epub 2013 Mar 8.

Parcellating an individual subject's cortical and subcortical brain structures using snowball sampling of resting-state correlations.

Author information

1
Department of Neurology, gwig@utdallas.edu.
2
Department of Neurology.
3
Department of Psychology, Washington University, St. Louis, MO, USA.
4
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA and.
5
Department of Neurology, Department of Radiology.
6
Department of Neurology, Department of Radiology, Department of Pediatrics.
7
Department of Neurology, Department of Radiology, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, USA and Department of Psychology, Washington University, St. Louis, MO, USA.

Abstract

We describe methods for parcellating an individual subject's cortical and subcortical brain structures using resting-state functional correlations (RSFCs). Inspired by approaches from social network analysis, we first describe the application of snowball sampling on RSFC data (RSFC-Snowballing) to identify the centers of cortical areas, subdivisions of subcortical nuclei, and the cerebellum. RSFC-Snowballing parcellation is then compared with parcellation derived from identifying locations where RSFC maps exhibit abrupt transitions (RSFC-Boundary Mapping). RSFC-Snowballing and RSFC-Boundary Mapping largely complement one another, but also provide unique parcellation information; together, the methods identify independent entities with distinct functional correlations across many cortical and subcortical locations in the brain. RSFC parcellation is relatively reliable within a subject scanned across multiple days, and while the locations of many area centers and boundaries appear to exhibit considerable overlap across subjects, there is also cross-subject variability-reinforcing the motivation to parcellate brains at the level of individuals. Finally, examination of a large meta-analysis of task-evoked functional magnetic resonance imaging data reveals that area centers defined by task-evoked activity exhibit correspondence with area centers defined by RSFC-Snowballing. This observation provides important evidence for the ability of RSFC to parcellate broad expanses of an individual's brain into functionally meaningful units.

KEYWORDS:

boundary mapping; brain area parcellation; brain networks; individual differences; resting-state functional correlations; snowball sampling

PMID:
23476025
PMCID:
PMC4089380
DOI:
10.1093/cercor/bht056
[Indexed for MEDLINE]
Free PMC Article

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