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Am J Hematol. 2013 May;88(5):409-15. doi: 10.1002/ajh.23405. Epub 2013 Mar 8.

Treating iron overload in patients with non-transfusion-dependent thalassemia.

Author information

1
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Abstract

Despite receiving no or only occasional blood transfusions, patients with non-transfusion-dependent thalassemia (NTDT) have increased intestinal iron absorption and can accumulate iron to levels comparable with transfusion-dependent patients. This iron accumulation occurs more slowly in NTDT patients compared to transfusion-dependent thalassemia patients, and complications do not arise until later in life. It remains crucial for these patients' health to monitor and appropriately treat their iron burden. Based on recent data, including a randomized clinical trial on iron chelation in NTDT, a simple iron chelation treatment algorithm is presented to assist physicians with monitoring iron burden and initiating chelation therapy in this group of patients.

PMID:
23475638
PMCID:
PMC3652024
DOI:
10.1002/ajh.23405
[Indexed for MEDLINE]
Free PMC Article

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