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Cell Mol Life Sci. 2013 May;70(10):1753-61. doi: 10.1007/s00018-013-1282-8. Epub 2013 Mar 12.

Vascular endothelial growth factors (VEGFs) and stroke.

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1
Buck Institute for Research on Aging, Novato, CA 94945, USA. dgreenberg@buckinstitute.org

Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

PMID:
23475070
PMCID:
PMC3634892
DOI:
10.1007/s00018-013-1282-8
[Indexed for MEDLINE]
Free PMC Article
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