Format

Send to

Choose Destination
Nat Rev Microbiol. 2013 Apr;11(4):264-76. doi: 10.1038/nrmicro2992. Epub 2013 Mar 11.

A cornucopia of human polyomaviruses.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. james_decaprio@dfci.harvard.edu

Abstract

During the past 6 years, focused virus hunting has led to the discovery of nine new human polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell carcinoma, a lethal skin cell cancer. The discovery of so many new and highly divergent human polyomaviruses raises key questions regarding their evolution, tropism, latency, reactivation, immune evasion and contribution to disease. This Review describes the similarities and differences among the new human polyomaviruses and discusses how these viruses might interact with their human host.

PMID:
23474680
PMCID:
PMC3928796
DOI:
10.1038/nrmicro2992
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center