Send to

Choose Destination
IEEE Trans Nanobioscience. 2013 Mar;12(1):60-3. doi: 10.1109/TNB.2012.2230024.

Kinetics of cisplatin release by in-vitro using poly(D,L-lactide) coated Fe3O4 nanocarriers.

Author information

Department of Medical Bionanotechnology, Chettinad Hospital and Research Institute, Kelambakkam, India.


Applications of nanoparticles as drug delivery systems for anticancer therapeutics have great potential to revolutionize the future of cancer therapy. In the present study, Fe3O4 nanoparticles were synthesized by co-precipitation method in the alkaline pH medium. The synthesized nanoparticles were characterized by X-ray diffraction and high resolution scanning electron microscope techniques. These analyses reveal the formation of agglomerated single phase Fe3O4 nanoparticles with average crystallite size of 8 nm. The emulsification solvent evaporation method was employed to prepare anti-cancer drug cisplatin loaded biodegradable poly (D, L-lactide) coated magnetic carriers. Fourier transform infrared spectroscopy shows the presence of cisplatin loaded poly(D,L-lactide) coating on the surface of Fe3O4 nanoparticles. Cisplatin loading efficiency and kinetics of drug release in-vitro were investigated by UV-Vis spectrophotometer. The loading efficiency of the drug was found to be 80% and from that 53% of the drug was released over a period of 70 h in phosphate buffer saline (pH 7.4) at ~ 37°C.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IEEE Engineering in Medicine and Biology Society
Loading ...
Support Center