Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Biotechnol. 2013 Dec;24(6):1078-88. doi: 10.1016/j.copbio.2013.02.015. Epub 2013 Mar 7.

Vaccine design: emerging concepts and renewed optimism.

Author information

1
Thayer School of Engineering, Dartmouth College, NH, USA.

Abstract

Arguably, vaccination represents the single most effective medical intervention ever developed. Yet, vaccines have failed to provide any or adequate protection against some of the most significant global diseases. The pathogens responsible for these vaccine-recalcitrant diseases have properties that allow them to evade immune surveillance and misdirect or eliminate the immune response. However, genomic and systems biology tools, novel adjuvants and delivery systems, and refined molecular insight into protective immunity have started to redefine the landscape, and results from recent efficacy trials of HIV and malaria vaccines have instilled hope that another golden age of vaccines may be on the horizon.

PMID:
23474232
PMCID:
PMC3696422
DOI:
10.1016/j.copbio.2013.02.015
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center