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Can J Cardiol. 2013 Sep;29(9):1138.e7-8. doi: 10.1016/j.cjca.2012.12.011. Epub 2013 Mar 6.

Giant cell myocarditis in a patient with a spondyloarthropathy after a drug hypersensitivity reaction.

Author information

1
Divisions of Cardiology, Cardiac Surgery and Nursing, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Abstract

A young woman thought to have seronegative rheumatoid arthritis developed Stevens-Johnson syndrome after treatment with sulfasalazine; this resolved with prednisone. Later she was found to be HLA-B27-positive in keeping with a spondyloarthropathy. Soon afterward, she developed clinical myopericarditis and cardiogenic shock that responded initially to methylprednisolone and intravenous immunoglobulin, but recurred. An endomyocardial biopsy demonstrated active myocarditis with a mixed cell composition including rare giant cells, but not enough to classify it as giant cell myocarditis. Heart failure symptoms returned and she eventually required a heart transplant; the explanted heart showed giant cell myocarditis.

PMID:
23474137
DOI:
10.1016/j.cjca.2012.12.011
[Indexed for MEDLINE]
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