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Alzheimers Dement. 2013 Nov;9(6):699-705. doi: 10.1016/j.jalz.2012.11.011. Epub 2013 Mar 7.

Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old.

Author information

1
Department of Pharmaceutical Sciences, School of Pharmacy, Regis University, Denver, CO, USA. Electronic address: dberlau@regis.edu.

Abstract

OBJECTIVE:

Apolipoprotein E (APOE) ε2 carriers may be protected from dementia because of reduced levels of cortical β-amyloid. In the oldest-old, however, APOE ε2 carriers have high β-amyloid plaque scores and preserved cognition. We compared different measures of β-amyloid pathology across APOE genotypes in the oldest-old, and their relationship with dementia.

METHODS:

The study included 96 participants from The 90+ Study. Using all information, dementia diagnoses were made. Neuropathological examination included staging for amyloid plaques and β-amyloid cortical percent area stained by NAB228 antibody.

RESULTS:

Both APOE ε2 and APOE ε4 carriers had high Consortium to Establish a Registry for Alzheimer's Disease plaque scores. However, APOE ε2 carriers had low cortical β-amyloid percent areas. β-amyloid percent area was associated with dementia across APOE genotypes.

CONCLUSIONS:

Lower levels of percent area in APOE ε2 carriers may reflect lower total β-amyloid and may contribute to APOE ε2 carriers' decreased risk of dementia, despite high β-amyloid plaque scores. The relationship between β-amyloid plaques and dementia in the oldest-old may vary by APOE genotype.

KEYWORDS:

Alzheimer; Apolipoprotein E; Beta-amyloid; Dementia; Oldest-old

PMID:
23474043
PMCID:
PMC3971646
DOI:
10.1016/j.jalz.2012.11.011
[Indexed for MEDLINE]
Free PMC Article

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