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PLoS One. 2013;8(3):e58090. doi: 10.1371/journal.pone.0058090. Epub 2013 Mar 5.

Exercise-induced changes in iron status and hepcidin response in female runners.

Author information

1
Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia.

Abstract

BACKGROUND AND AIMS:

Exercise-induced iron deficiency is a common finding in endurance athletes. It has been suggested recently that hepcidin may be an important mediator in this process.

OBJECTIVE:

To determine hepcidin levels and markers of iron status during long-term exercise training in female runners with depleted and normal iron stores.

METHODS:

Fourteen runners were divided into two groups according to iron status. Blood samples were taken during a period of eight weeks at baseline, after training and after ten days' recovery phase.

RESULTS:

Of 14 runners, 7 were iron deficient at baseline and 10 after training. Hepcidin was lower at recovery compared with baseline (p<0.05). The mean cell haemoglobin content, haemoglobin content per reticulocyte and total iron binding capacity all decreased, whereas soluble transferrin receptor and hypochromic red cells increased after training and recovery (p<0.05 for all).

CONCLUSION:

The prevalence of depleted iron stores was 71% at the end of the training phase. Hepcidin and iron stores decreased during long-term running training and did not recover after ten days, regardless of baseline iron status.

PMID:
23472137
PMCID:
PMC3589469
DOI:
10.1371/journal.pone.0058090
[Indexed for MEDLINE]
Free PMC Article
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