DNA-templated Ag nanoclusters as signal transducers for a label-free and resettable keypad lock

Chem Commun (Camb). 2013 Apr 18;49(30):3107-9. doi: 10.1039/c3cc39272d. Epub 2013 Mar 8.

Abstract

We present a unique, label-free and resettable molecular keypad lock that utilizes DNA-modulated Ag nanoclusters (Ag NCs) as signal responsers. The present work demonstrates the first example that exonuclease-catalyzed DNA hydrolysis reaction could be used to achieve the RESET function of a molecular keypad without complicated procedures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • DNA / chemistry*
  • DNA / metabolism*
  • Exonucleases / chemistry
  • Exonucleases / metabolism*
  • Hydrolysis
  • Metal Nanoparticles / chemistry*
  • Signal Transduction*
  • Silver / chemistry*
  • Silver / metabolism
  • Spectrometry, Fluorescence

Substances

  • Silver
  • DNA
  • Exonucleases