Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2013 Apr;13(4):280-93. doi: 10.1038/nri3421. Epub 2013 Mar 8.

Population genetic tools for dissecting innate immunity in humans.

Author information

1
Institut Pasteur, Unit of Human Evolutionary Genetics, Paris, France. quintana@pasteur.fr

Abstract

Innate immunity involves direct interactions between the host and microorganisms, both pathogenic and symbiotic, so natural selection is expected to strongly influence genes involved in these processes. Population genetics investigates the impact of past natural selection events on the genome of present-day human populations, and it complements immunological as well as clinical and epidemiological genetic studies. Recent data show that the impact of selection on the different families of innate immune receptors and their downstream signalling molecules varies considerably. This Review discusses these findings and highlights how they help to delineate the relative functional importance of innate immune pathways, which can range from being essential to being redundant.

PMID:
23470320
PMCID:
PMC4015519
DOI:
10.1038/nri3421
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center