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Zhonghua Nan Ke Xue. 2013 Jan;19(1):72-6.

[Sperm DNA integrity of infertile males with hepatitis B virus infection].

[Article in Chinese]

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Department of Urology, The First Peoples Hospital of Foshan, Foshan, Guangdong 528000, China.



To investigate sperm DNA integrity in male infertility patients with hepatitis B virus (HBV) infection.


This study included 90 infertile men with HBV infection (group A), 82 infertile men without HBV infection (group B) and 70 normal fertile men (group C). We detected sperm DNA integrity among the subjects, including DNA fragmentation index (DFI) and high DNA stainability (HDS), by sperm chromatin structure assay (SCSA), and compared them among the three groups.


DFI was higher in group A ([28.17 +/- 13.06]%) than in B ([26.64 +/- 9.79]%) and C ([15.67 +/- 4.73]%), significantly higher in A and B than in C (P < 0.05) but with no significant difference between A and B (P > 0.05). HDS was higher in group A ([10.83 +/- 5.601]%) than in B ([9.04 +/- 3.48]%) and C ([8.04-2.25]%), with significant difference between A and C (P < 0.05).


Sperm DNA integrity of infertile males is significantly different from that of normal fertile men, and infertility with HBV infection further impairs sperm DNA, which is manifested by abnormal sperm nuclear maturity.

[Indexed for MEDLINE]

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