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Zhonghua Nan Ke Xue. 2013 Jan;19(1):19-23.

[Establishment of cryptorchid infertile models by postnatal injection of estradiol in mice].

[Article in Chinese]

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Department of Urology, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, China.



To investigate the incidence and spermatogenesis of cryptorchid testes induced by postnatal injection of estradiol.


Ninety male newborn Balb/C mice were randomly divided into an experimental (n = 60), a solvent control (n = 20) and a normal control group (n = 10). The experimental mice were again assigned to a 4-week, a 6-week, an 8-week, and a 10-week subgroup, and injected subcutaneously with 17-beta estradiol (5 microg/d) from 3 to 28, 3 to 42, 3 to 56 and 3 to 70 days after birth, respectively. The incidence of cryptorchidism and morphological changes of the testes were observed at 2 weeks after drug withdrawal.


The incidence rates of cryptorchidism in the 4-, 6-, 8- and 10-week groups were 0%, 26.7%, 60% and 60%, respectively, but no cryptorchidism occurred in the solvent and normal control groups. The 4- and 6-week groups showed autonomous descent of the cryptorchid testes and recovery of spermatogenesis after drug withdrawal. The models became stable and no spermatogenesis recovery was observed after 8 weeks of continuous medication.


Stable cryptorchid infertile models can be established in mice by postnatally continuous injection of estradiol for over 8 weeks.

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