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Cancer Prev Res (Phila). 2013 May;6(5):387-400. doi: 10.1158/1940-6207.CAPR-12-0410. Epub 2013 Mar 6.

New perspectives of curcumin in cancer prevention.

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1
Department of Hematology and Medical Oncology, 1365 Clifton Road, C-3094, Winship Cancer Institute of Emory University, School of Medicine, Atlanta, GA, 30322, USA.

Erratum in

Abstract

Numerous natural compounds have been extensively investigated for their potential for cancer prevention over the decades. Curcumin, from Curcuma longa, is a highly promising natural compound that can be potentially used for chemoprevention of multiple cancers. Curcumin modulates multiple molecular pathways involved in the lengthy carcinogenesis process to exert its chemopreventive effects through several mechanisms: promoting apoptosis, inhibiting survival signals, scavenging reactive oxidative species (ROS), and reducing the inflammatory cancer microenvironment. Curcumin fulfills the characteristics for an ideal chemopreventive agent with its low toxicity, affordability, and easy accessibility. Nonetheless, the clinical application of curcumin is currently compromised by its poor bioavailability. Here, we review the potential of curcumin in cancer prevention, its molecular targets, and mechanisms of action. Finally, we suggest specific recommendations to improve its efficacy and bioavailability for clinical applications.

PMID:
23466484
PMCID:
PMC3693758
DOI:
10.1158/1940-6207.CAPR-12-0410
[Indexed for MEDLINE]
Free PMC Article

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