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Curr Opin Cell Biol. 2013 Jun;25(3):327-33. doi: 10.1016/j.ceb.2013.02.003. Epub 2013 Mar 1.

Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans.

Author information

1
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. dorsettd@slu.edu

Abstract

Cohesin is an evolutionarily ancient multisubunit protein complex with a deeply conserved function: it provides cohesion between sister chromatids from the time of DNA replication in S-phase until mitosis. This cohesion facilitates repair of damage that occurs during DNA replication, and, crucially, enforces faithful segregation of chromosomes upon cell division. Cohesin also influences gene expression, and relative to sister chromatid cohesion, gene expression is exquisitely sensitive to moderate changes in cohesin activity. Early studies revealed differences in cohesin's roles in gene expression between various organisms. In all organisms examined, however, cohesin marks a subset of active genes. This review focuses on the roles of cohesin at active genes, and to what extent these roles are conserved between organisms.

PMID:
23465542
PMCID:
PMC3691354
DOI:
10.1016/j.ceb.2013.02.003
[Indexed for MEDLINE]
Free PMC Article

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