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Biochem Biophys Res Commun. 1990 May 16;168(3):912-6.

Resolution of racemic carbovir and selective inhibition of human immunodeficiency virus by the (-) enantiomer.

Author information

1
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.

Abstract

(+-) Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which is undergoing preclinical evaluation for the treatment of AIDS. Racemic carbovir was separated into its D and L enantiomers by the action of adenosine deaminase on the 2,6-diaminopurine precursor. Subsequent evaluation of the enantiomers against human immunodeficiency virus type 1 revealed that the antiviral activity of carbovir resides in the (-) isomer that is analogous to the nucleoside, beta-D-2',3'-didehydro-2',3'-dideoxyguanosine.

PMID:
2346492
DOI:
10.1016/0006-291x(90)91115-9
[Indexed for MEDLINE]

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